Ontology highlight
ABSTRACT:
SUBMITTER: DeVoss JJ
PROVIDER: S-EPMC2851482 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
DeVoss Jason J JJ LeClair Norbert P NP Hou Yafei Y Grewal Navdeep K NK Johannes Kellsey P KP Lu Wen W Yang Ting T Meagher Craig C Fong Lawrence L Strauss Erich C EC Anderson Mark S MS
Journal of immunology (Baltimore, Md. : 1950) 20100317 8
Sjögren's Syndrome (SS) is a human autoimmune disease characterized by immune-mediated destruction of the lacrimal and salivary glands. In this study, we show that the Aire-deficient mouse represents a new tool to investigate autoimmune dacryoadenitis and keratoconjunctivitis sicca, features of SS. Previous work in the Aire-deficient mouse suggested a role for alpha-fodrin, a ubiquitous Ag, in the disease process. Using an unbiased biochemical approach, however, we have identified a novel lacrim ...[more]