Ontology highlight
ABSTRACT:
SUBMITTER: Langlois RA
PROVIDER: S-EPMC2851488 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Langlois Ryan A RA Legge Kevin L KL
Journal of immunology (Baltimore, Md. : 1950) 20100310 8
Previous studies have shown that the reduction in CD8 T cell immunity observed during high-dose influenza A virus (IAV) infection is mediated via lymph node (LN) dendritic cells (DCs) that express Fas ligand (FasL) and drive FasL-Fas (DC-T)-induced apoptosis. However, the specific DC subset(s) within the LN and the additional factors required for DC-mediated elimination of IAV-specific CD8 T cells remain unknown. In this paper, we demonstrate that plasmacytoid DCs (pDCs), which downregulate FasL ...[more]