Ontology highlight
ABSTRACT:
SUBMITTER: Luo Y
PROVIDER: S-EPMC2851565 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Luo Yuping Y Shan Ge G Guo Weixiang W Smrt Richard D RD Johnson Eric B EB Li Xuekun X Pfeiffer Rebecca L RL Szulwach Keith E KE Duan Ranhui R Barkho Basam Z BZ Li Wendi W Liu Changmei C Jin Peng P Zhao Xinyu X
PLoS genetics 20100408 4
Fragile X syndrome (FXS), the most common form of inherited mental retardation, is caused by the loss of functional fragile X mental retardation protein (FMRP). FMRP is an RNA-binding protein that can regulate the translation of specific mRNAs. Adult neurogenesis, a process considered important for neuroplasticity and memory, is regulated at multiple molecular levels. In this study, we investigated whether Fmrp deficiency affects adult neurogenesis. We show that in a mouse model of fragile X syn ...[more]