Ontology highlight
ABSTRACT:
SUBMITTER: Seshadri S
PROVIDER: S-EPMC2851766 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Seshadri Saurav S Kamiya Atsushi A Yokota Yukako Y Prikulis Ingrid I Kano Shin-ichi S Hayashi-Takagi Akiko A Stanco Amelia A Eom Tae-Yeon TY Rao Sarada S Ishizuka Koko K Wong Philip P Korth Carsten C Anton E S ES Sawa Akira A
Proceedings of the National Academy of Sciences of the United States of America 20100308 12
Neuregulin-1 (NRG1) and Disrupted-in-Schizophrenia-1 (DISC1) are promising susceptibility factors for schizophrenia. Both are multifunctional proteins with roles in a variety of neurodevelopmental processes, including progenitor cell proliferation, migration, and differentiation. Here, we provide evidence linking these factors together in a single pathway, which is mediated by ErbB receptors and PI3K/Akt. We show that signaling by NRG1 and NRG2, but not NRG3, increase expression of an isoform of ...[more]