Ontology highlight
ABSTRACT:
SUBMITTER: Nabeyama A
PROVIDER: S-EPMC2852021 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Nabeyama Ami A Kurita Ai A Asano Kenichi K Miyake Yasunobu Y Yasuda Takuwa T Miura Ikuo I Nishitai Gen G Arakawa Satoko S Shimizu Shigeomi S Wakana Shigeharu S Yoshida Hisahiro H Tanaka Masato M
Proceedings of the National Academy of Sciences of the United States of America 20100322 14
During the course of inflammation and its resolution, macrophages are exposed to various cytotoxic materials, including reactive oxygen species. Thus, macrophages require a protective machinery against oxidative stress to survive at the inflammatory site. Here, we showed that xCT, a component of transport system x(c)(-), was significantly up-regulated in activated infiltrating cells, including macrophages and neutrophils at the inflammatory site. System x(c)(-) mediates the uptake of extracellul ...[more]