Ontology highlight
ABSTRACT:
SUBMITTER: Chia DJ
PROVIDER: S-EPMC2852351 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Molecular endocrinology (Baltimore, Md.) 20100216 4
Many of the physiological actions of GH are mediated by IGF-I, a secreted 70-residue peptide whose gene expression is induced by GH in the liver and other tissues via mechanisms that remain incompletely characterized but depend on the transcription factor Stat5b. Here we investigate the chromatin landscape of the IGF-I gene in the liver of pituitary-deficient young adult male rats and assess the impact of a single systemic GH injection. Despite minimal ongoing transcription in the absence of GH, ...[more]