Ontology highlight
ABSTRACT:
SUBMITTER: Louderbough JM
PROVIDER: S-EPMC2852554 | biostudies-literature | 2010 Jan-Mar
REPOSITORIES: biostudies-literature
Cell adhesion & migration 20100129 1
EGFR, a critical regulator of oncogenic signaling during cancer progression, is capable of integrating multireceptor signaling pathways that promote metastasis. EGFR is subject to regulatory cues from the extracellular matrix (ECM), of which hyaluronan (HA) is a major component. In mammary tumors, HA is deposited in the ECM where it functions in biomechanical support and modulates intracellular signaling. We utilized a 3D collagen system in which HA is either polymerized in collagen matrix or pr ...[more]