Ontology highlight
ABSTRACT:
SUBMITTER: Lal A
PROVIDER: S-EPMC2853019 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Lal Ashish A Pan Yunfeng Y Navarro Francisco F Dykxhoorn Derek M DM Moreau Lisa L Meire Eti E Bentwich Zvi Z Lieberman Judy J Chowdhury Dipanjan D
Nature structural & molecular biology 20090419 5
Terminally differentiated cells have a reduced capacity to repair double-stranded breaks, but the molecular mechanism behind this downregulation is unclear. Here we find that miR-24 is upregulated during postmitotic differentiation of hematopoietic cell lines and regulates the histone variant H2AX, a protein that has a key role in the double-stranded break response. We show that the H2AX 3' untranslated region contains conserved miR-24 binding sites that are indeed regulated by miR-24. During te ...[more]