Ontology highlight
ABSTRACT:
SUBMITTER: Nicoloso MS
PROVIDER: S-EPMC2853025 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Nicoloso Milena S MS Sun Hao H Spizzo Riccardo R Kim Hyunsoo H Wickramasinghe Priyankara P Shimizu Masayoshi M Wojcik Sylwia E SE Ferdin Jana J Kunej Tanja T Xiao Lianchun L Manoukian Siranoush S Secreto Giorgio G Ravagnani Fernando F Wang Xuemei X Radice Paolo P Croce Carlo M CM Davuluri Ramana V RV Calin George A GA
Cancer research 20100323 7
Single-nucleotide polymorphisms (SNP) associated with polygenetic disorders, such as breast cancer (BC), can create, destroy, or modify microRNA (miRNA) binding sites; however, the extent to which SNPs interfere with miRNA gene regulation and affect cancer susceptibility remains largely unknown. We hypothesize that disruption of miRNA target binding by SNPs is a widespread mechanism relevant to cancer susceptibility. To test this, we analyzed SNPs known to be associated with BC risk, in silico a ...[more]