Anatomy of mouse recombination hot spots.
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ABSTRACT:
SUBMITTER: Wu ZK
PROVIDER: S-EPMC2853141 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
Anatomy of mouse recombination hot spots.
Wu Zhen K ZK Getun Irina V IV Bois Philippe R J PR
Nucleic acids research 20100115 7
Genome-wide analyses have suggested thousands of meiotic recombination hot spots across mammalian genomes. However, very few hot spots have been directly analyzed at a sub-kb scale for crossover (CO) activity. Using recombinant inbred strains as a CO library, here we report the identification and detailed characterization of seven new meiotic hot spots on mouse chromosome 19, more than doubling the number of currently available mouse hot spots. Although a shared feature is the narrow 1.5-2.5-kb ...[more]
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