Ontology highlight
ABSTRACT:
SUBMITTER: Scimemi A
PROVIDER: S-EPMC2853250 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Scimemi Annalisa A Tian Hua H Diamond Jeffrey S JS
The Journal of neuroscience : the official journal of the Society for Neuroscience 20091101 46
In the mammalian brain, the specificity of excitatory synaptic transmission depends on rapid diffusion of glutamate away from active synapses and the powerful uptake capacity of glutamate transporters in astrocytes. The extent to which neuronal glutamate transporters influence the lifetime of glutamate in the extracellular space remains unclear. Here we show that EAAC1, the predominant neuronal glutamate transporter at excitatory synapses in hippocampal area CA1, buffers glutamate released durin ...[more]