Dataset Information

Risk for asthma in offspring of asthmatic mothers versus fathers: a meta-analysis.

ABSTRACT:

Background

Many human epidemiologic studies demonstrate that maternal asthma confers greater risk of asthma to offspring than does paternal disease. However, a handful have shown the opposite. Given this disparity, a meta-analysis is necessary to determine the veracity and magnitude of the "maternal effect."

Methodology/principal findings

We screened the medical literature from 1966 to 2009 and performed a meta-analysis to compare the effect of maternal asthma vs. paternal asthma on offspring asthma susceptibility. Aggregating data from 33 studies, the odds ratio for asthma in children of asthmatic mothers compared with non-asthmatic mothers was significantly increased at 3.04 (95% confidence interval: 2.59-3.56). The corresponding odds ratio for asthma in children of asthmatic fathers was increased at 2.44 (2.14-2.79). When comparing the odds ratios, maternal asthma conferred greater risk of disease than did paternal asthma (3.04 vs. 2.44, p = 0.037). When analyzing the studies in which asthma was diagnosed by a physician the odds ratios were attenuated and no significant differences were observed (2.85 vs. 2.48, N = 18, p = 0.37). Similarly, no significant differences were observed between maternal and paternal odds ratios when analyzing the studies in which the patient population was 5 years or older (3.15 vs. 2.60, p = 0.14). However, in all cases the trend remained the same, that maternal asthma was a greater risk factor for asthma than paternal.

Conclusions/significance

The results show that maternal asthma increases offspring disease risk to a greater extent than paternal disease.

SUBMITTER: Lim RH

PROVIDER: S-EPMC2853568 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Risk for asthma in offspring of asthmatic mothers versus fathers: a meta-analysis.

Lim Robert H RH Kobzik Lester L Dahl Morten M

PloS one 20100412 4

<h4>Background</h4>Many human epidemiologic studies demonstrate that maternal asthma confers greater risk of asthma to offspring than does paternal disease. However, a handful have shown the opposite. Given this disparity, a meta-analysis is necessary to determine the veracity and magnitude of the "maternal effect."<h4>Methodology/principal findings</h4>We screened the medical literature from 1966 to 2009 and performed a meta-analysis to compare the effect of maternal asthma vs. paternal asthma ...[more]

PMID: 20405032

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Dataset Information

Risk for asthma in offspring of asthmatic mothers versus fathers: a meta-analysis.

Background

Methodology/principal findings

Conclusions/significance

Publications

Risk for asthma in offspring of asthmatic mothers versus fathers: a meta-analysis.

Similar Datasets

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