Ontology highlight
ABSTRACT:
SUBMITTER: Bhatnagar V
PROVIDER: S-EPMC2853591 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Bhatnagar Vibha V Garcia Erin P EP O'Connor Daniel T DT Brophy Victoria H VH Alcaraz John J Richard Erin E Bakris George L GL Middleton John P JP Norris Keith C KC Wright Jackson J Hiremath Leena L Contreras Gabriel G Appel Lawrence J LJ Lipkowitz Michael S MS
American journal of nephrology 20091112 2
<h4>Purpose</h4>To explore the association between CYP3A4 and CYP3A5 gene polymorphisms and blood pressure response to amlodipine among participants from the African-American Study of Kidney Disease and Hypertension Trial randomized to amlodipine (n = 164).<h4>Methods</h4>Cox proportional hazards models were used to determine the risk of reaching a target mean arterial pressure (MAP) of < or =107 mm Hg by CYP3A4 (A-392G and T16090C) and CYP3A5 (A6986G) gene polymorphisms, stratified by MAP rando ...[more]