Ontology highlight
ABSTRACT:
SUBMITTER: Anderson TJ
PROVIDER: S-EPMC2853733 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Anderson Tim J C TJ Nair Shalini S Nkhoma Standwell S Williams Jeff T JT Imwong Mallika M Yi Poravuth P Socheat Duong D Das Debashish D Chotivanich Kesinee K Day Nicholas P J NP White Nicholas J NJ Dondorp Arjen M AM
The Journal of infectious diseases 20100501 9
In western Cambodia, malaria parasites clear slowly from the blood after treatment with artemisinin derivatives, but it is unclear whether this results from parasite, host, or other factors specific to this population. We measured heritability of clearance rate by evaluating patients infected with identical or nonidentical parasite genotypes, using methods analogous to human twin studies. A substantial proportion (56%-58%) of the variation in clearance rate is explained by parasite genetics. Thi ...[more]