Homology Modelling of Human E1 Ubiquitin Activating Enzyme.
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ABSTRACT:
SUBMITTER: Brahemi G
PROVIDER: S-EPMC2853970 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Publications
Homology Modelling of Human E1 Ubiquitin Activating Enzyme.
Brahemi Ghali G Burger Angelika M AM Westwell Andrew D AD Brancale Andrea A
Letters in drug design & discovery 20100101 1
Human E1 is a key player in protein ubiquitination, however the E1 structure is not available. In this paper, we describe the derivation of a human E1 structure using molecular modelling based on the crystal structure of S. cerevisiae E1 and M. Musculus E1. Key interactions between our E1 model and ubiquitin are also discussed. ...[more]
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