Ontology highlight
ABSTRACT:
SUBMITTER: Koglin A
PROVIDER: S-EPMC2854587 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Koglin Alexander A Löhr Frank F Bernhard Frank F Rogov Vladimir V VV Frueh Dominique P DP Strieter Eric R ER Mofid Mohammad R MR Güntert Peter P Wagner Gerhard G Walsh Christopher T CT Marahiel Mohamed A MA Dötsch Volker V
Nature 20080801 7206
Non-ribosomal peptide synthetases (NRPS) and polyketide synthases (PKS) found in bacteria, fungi and plants use two different types of thioesterases for the production of highly active biological compounds. Type I thioesterases (TEI) catalyse the release step from the assembly line of the final product where it is transported from one reaction centre to the next as a thioester linked to a 4'-phosphopantetheine (4'-PP) cofactor that is covalently attached to thiolation (T) domains. The second enz ...[more]