A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases.
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ABSTRACT:
SUBMITTER: Hirsch HA
PROVIDER: S-EPMC2854678 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases.
Hirsch Heather A HA Iliopoulos Dimitrios D Joshi Amita A Zhang Yong Y Jaeger Savina A SA Bulyk Martha M Tsichlis Philip N PN Shirley Liu X X Struhl Kevin K
Cancer cell 20100401 4
Transcriptional profiling of two isogenic models of transformation identifies a gene signature linking cancer with inflammatory and metabolic diseases. In accord with this common transcriptional program, many drugs used for treatment of diabetes and cardiovascular diseases inhibit transformation and tumor growth. Unexpectedly, lipid metabolism genes are important for transformation and are upregulated in cancer tissues. As in atherosclerosis, oxidized LDL and its receptor OLR1 activate the infla ...[more]
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