Ontology highlight
ABSTRACT:
SUBMITTER: Davis ME
PROVIDER: S-EPMC2855406 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Davis Mark E ME Zuckerman Jonathan E JE Choi Chung Hang J CH Seligson David D Tolcher Anthony A Alabi Christopher A CA Yen Yun Y Heidel Jeremy D JD Ribas Antoni A
Nature 20100321 7291
Therapeutics that are designed to engage RNA interference (RNAi) pathways have the potential to provide new, major ways of imparting therapy to patients. Long, double-stranded RNAs were first shown to mediate RNAi in Caenorhabditis elegans, and the potential use of RNAi for human therapy has been demonstrated by the finding that small interfering RNAs (siRNAs; approximately 21-base-pair double-stranded RNA) can elicit RNAi in mammalian cells without producing an interferon response. We are at pr ...[more]