Enhanced antibody half-life improves in vivo activity.
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ABSTRACT:
SUBMITTER: Zalevsky J
PROVIDER: S-EPMC2855492 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Publications
Enhanced antibody half-life improves in vivo activity.
Zalevsky Jonathan J Chamberlain Aaron K AK Horton Holly M HM Karki Sher S Leung Irene W L IW Sproule Thomas J TJ Lazar Greg A GA Roopenian Derry C DC Desjarlais John R JR
Nature biotechnology 20100117 2
Improved affinity for the neonatal Fc receptor (FcRn) is known to extend antibody half-life in vivo. However, this has never been linked with enhanced therapeutic efficacy. We tested whether antibodies with half-lives extended up to fivefold in human (h)FcRn transgenic mice and threefold in cynomolgus monkeys retain efficacy at longer dosing intervals. We observed that prolonged exposure due to FcRn-mediated enhancement of half-life improved antitumor activity of Fc-engineered antibodies in an h ...[more]
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