Identification of specific lipid-binding sites in integral membrane proteins.
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ABSTRACT:
SUBMITTER: Lensink MF
PROVIDER: S-EPMC2856259 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
Identification of specific lipid-binding sites in integral membrane proteins.
Lensink Marc F MF Govaerts Cédric C Ruysschaert Jean-Marie JM
The Journal of biological chemistry 20100205 14
Protein-lipid interactions are increasingly recognized as central to the structure and function of membrane proteins. However, with the exception of simplified models, specific protein-lipid interactions are particularly difficult to highlight experimentally. Here, we used molecular dynamics simulations to identify a specific protein-lipid interaction in lactose permease, a prototypical model for transmembrane proteins. The interactions can be correlated with the functional dependence of the pro ...[more]
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