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ABSTRACT: Background
The anterior cruciate ligament (ACL) fails to heal after traumatic rupture. Furthermore, large-animal models have recently shown that 1-month functional ACL healing is augmented after suture repair when a bioactive scaffold is placed in the tear site.Hypothesis
At the time of suture repair, placement of a bioactive scaffold in the ACL wound site would improve the structural properties of the tissue.Study design
Controlled laboratory study.Methods
Twenty-seven knees in immature pigs underwent ACL transection and suture repair. A collagen-platelet composite (CPC) was used to supplement the repair in 14 knees. Knees were harvested at 4 weeks, 6 weeks, and 3 months. Mechanical testing and histologic analysis were performed.Results
The addition of a CPC to a suture repair resulted in improvements in yield load and linear stiffness of the repair tissue at 3 months, as well as a significant increase in cell density. A reduction in yield load and stiffness occurred at the 6-week time point in both groups, a phase when revascularization was noted.Conclusion
The addition of a CPC to a suture repair enhanced the structural properties of the ACL, and the improvement was associated with increased cellularity within the healing ligament.Clinical relevance
The addition of a bioactive scaffold to the wound site improved the functional healing of the ACL after suture repair. The decreased repair strength during revascularization may indicate a need to protect the repair site through this period.
SUBMITTER: Joshi SM
PROVIDER: S-EPMC2856313 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Joshi Shilpa M SM Mastrangelo Ashley N AN Magarian Elise M EM Fleming Braden C BC Murray Martha M MM
The American journal of sports medicine 20091201 12
<h4>Background</h4>The anterior cruciate ligament (ACL) fails to heal after traumatic rupture. Furthermore, large-animal models have recently shown that 1-month functional ACL healing is augmented after suture repair when a bioactive scaffold is placed in the tear site.<h4>Hypothesis</h4>At the time of suture repair, placement of a bioactive scaffold in the ACL wound site would improve the structural properties of the tissue.<h4>Study design</h4>Controlled laboratory study.<h4>Methods</h4>Twenty ...[more]