Ontology highlight
ABSTRACT:
SUBMITTER: Belanto JJ
PROVIDER: S-EPMC2856642 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Neuromuscular disorders : NMD 20100118 2
Glucocorticoids are beneficial in many muscular dystrophies but they are ineffective in treating dysferlinopathy, a rare muscular dystrophy caused by loss of dysferlin. We sought to understand the molecular basis for this disparity by studying the effects of a glucocorticoid on differentiation of the myoblast cell line, C2C12, and dysferlin-deficient C2C12s. We found that pharmacologic doses of dexamethasone enhanced the myogenic fusion efficiency of C2C12s and increased the induction of dysferl ...[more]