Ontology highlight
ABSTRACT:
SUBMITTER: Deharvengt SJ
PROVIDER: S-EPMC2856737 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Deharvengt S J SJ Gunn J R JR Pickett S B SB Korc M M
Cancer gene therapy 20091023 5
The aim of this study was to assess the biological consequences of cyclin D1 silencing in pancreatic cancer cells. A replication-defective lentivirus based small hairpin RNA (shRNA) system targeting cyclin D1 caused a marked reduction in cyclin D1 protein levels in ASPC-1 and BxPC3 pancreatic cancer cell lines in conjunction with decreased cell growth and invasiveness in vitro. Moreover, a single intratumoral injection of the recombinant lentivirus targeting cyclin D1 attenuated the growth of pr ...[more]