Ontology highlight
ABSTRACT:
SUBMITTER: Stein JL
PROVIDER: S-EPMC2856746 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Stein Jason L JL Hua Xue X Morra Jonathan H JH Lee Suh S Hibar Derrek P DP Ho April J AJ Leow Alex D AD Toga Arthur W AW Sul Jae Hoon JH Kang Hyun Min HM Eskin Eleazar E Saykin Andrew J AJ Shen Li L Foroud Tatiana T Pankratz Nathan N Huentelman Matthew J MJ Craig David W DW Gerber Jill D JD Allen April N AN Corneveaux Jason J JJ Stephan Dietrich A DA Webster Jennifer J DeChairo Bryan M BM Potkin Steven G SG Jack Clifford R CR Weiner Michael W MW Thompson Paul M PM
NeuroImage 20100301 2
In a genome-wide association study of structural brain degeneration, we mapped the 3D profile of temporal lobe volume differences in 742 brain MRI scans of Alzheimer's disease patients, mildly impaired, and healthy elderly subjects. After searching 546,314 genomic markers, 2 single nucleotide polymorphisms (SNPs) were associated with bilateral temporal lobe volume (P<5 x 10(-7)). One SNP, rs10845840, is located in the GRIN2B gene which encodes the N-methyl-d-aspartate (NMDA) glutamate receptor N ...[more]