Ontology highlight
ABSTRACT:
SUBMITTER: Van C
PROVIDER: S-EPMC2856894 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Van Christopher C Yan Shan S Michael W Matthew WM Waga Shou S Cimprich Karlene A KA
The Journal of cell biology 20100412 2
Stalled replication forks activate and are stabilized by the ATR (ataxia-telangiectasia mutated and Rad3 related)-mediated checkpoint, but ultimately, they must also recover from the arrest. Although primed single-stranded DNA (ssDNA) is sufficient for checkpoint activation, it is still unknown how this signal is generated at a stalled replication fork. Furthermore, it is not clear how recovery and fork restart occur in higher eukaryotes. Using Xenopus laevis egg extracts, we show that DNA repli ...[more]