Ontology highlight
ABSTRACT:
SUBMITTER: Gavet O
PROVIDER: S-EPMC2856909 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Gavet Olivier O Pines Jonathon J
The Journal of cell biology 20100401 2
The cyclin B-Cdk1 kinase triggers mitosis in most eukaryotes. In animal cells, cyclin B shuttles between the nucleus and cytoplasm in interphase before rapidly accumulating in the nucleus at prophase, which promotes disassembly of the nuclear lamina and nuclear envelope breakdown (NEBD). What triggers the nuclear accumulation of cyclin B1 is presently unclear, although the prevailing view is that the Plk1 kinase inhibits its nuclear export. In this study, we use a biosensor specific for cyclin B ...[more]