ZAP-70: an essential kinase in T-cell signaling.
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ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC2857167 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Publications
ZAP-70: an essential kinase in T-cell signaling.
Wang Haopeng H Kadlecek Theresa A TA Au-Yeung Byron B BB Goodfellow Hanna E Sjölin HE Hsu Lih-Yun LY Freedman Tanya S TS Weiss Arthur A
Cold Spring Harbor perspectives in biology 20100501 5
ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease. We also describe a model experimental system in which ZAP-70 function can be interrupted by a small chemical inhibitor. ...[more]
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