Single-nucleotide polymorphisms in the p53 signaling pathway.
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ABSTRACT:
SUBMITTER: Grochola LF
PROVIDER: S-EPMC2857176 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Publications
Single-nucleotide polymorphisms in the p53 signaling pathway.
Grochola Lukasz F LF Zeron-Medina Jorge J Mériaux Sophie S Bond Gareth L GL
Cold Spring Harbor perspectives in biology 20091209 5
The p53 tumor suppressor pathway is central both in reducing cancer frequency in vertebrates and in mediating the response of commonly used cancer therapies. This article aims to summarize and discuss a large body of evidence suggesting that the p53 pathway harbors functional inherited single-nucleotide polymorphisms (SNPs) that affect p53 signaling in cells, resulting in differences in cancer risk and clinical outcome in humans. The insights gained through these studies into how the functional ...[more]
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