Ontology highlight
ABSTRACT:
SUBMITTER: Prieto ML
PROVIDER: S-EPMC2857311 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Prieto Martin Loynaz ML Wollmuth Lonnie P LP
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100301 12
AMPA receptors are ligand-gated ion channels that show multiple conductance levels, indicating that gating of individual AMPA subunits is to some extent independent of the other subunits. To study AMPAR subunit interactions during activation gating, we recorded from single channels in the absence of channel block and desensitization and at negative and positive membrane potentials. In saturating glutamate, the relative occupancies of the various conductance levels are consistent with complete su ...[more]