Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos.
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ABSTRACT:
SUBMITTER: Vitale I
PROVIDER: S-EPMC2857458 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos.
Vitale Ilio I Senovilla Laura L Jemaà Mohamed M Michaud Mickaël M Galluzzi Lorenzo L Kepp Oliver O Nanty Lisa L Criollo Alfredo A Rello-Varona Santiago S Manic Gwenola G Métivier Didier D Vivet Sonia S Tajeddine Nicolas N Joza Nicholas N Valent Alexander A Castedo Maria M Kroemer Guido G
The EMBO journal 20100225 7
Tetraploidy can constitute a metastable intermediate between normal diploidy and oncogenic aneuploidy. Here, we show that the absence of p53 is not only permissive for the survival but also for multipolar asymmetric divisions of tetraploid cells, which lead to the generation of aneuploid cells with a near-to-diploid chromosome content. Multipolar mitoses (which reduce the tetraploid genome to a sub-tetraploid state) are more frequent when p53 is downregulated and the product of the Mos oncogene ...[more]
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