Ontology highlight
ABSTRACT:
SUBMITTER: Striebel F
PROVIDER: S-EPMC2857465 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Striebel Frank F Hunkeler Moritz M Summer Heike H Weber-Ban Eilika E
The EMBO journal 20100304 7
Mycobacterium tuberculosis, along with other actinobacteria, harbours proteasomes in addition to members of the general bacterial repertoire of degradation complexes. In analogy to ubiquitination in eukaryotes, substrates are tagged for proteasomal degradation with prokaryotic ubiquitin-like protein (Pup) that is recognized by the N-terminal coiled-coil domain of the ATPase Mpa (also called ARC). Here, we reconstitute the entire mycobacterial proteasome degradation system for pupylated substrate ...[more]