Ontology highlight
ABSTRACT:
SUBMITTER: Mathur D
PROVIDER: S-EPMC2857772 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20100101 5962
Stem cell niches are locations where stem cells reside and self-renew. Although studies have shown how niches maintain stem cell fate during tissue homeostasis, less is known about their roles in establishing stem cells. The adult Drosophila midgut is maintained by intestinal stem cells (ISCs); however, how they are established is unknown. Here, we show that an ISC progenitor generates a niche cell via Notch signaling. This niche uses the bone morphogenetic protein 2/4 homolog, decapentaplegic, ...[more]