Ontology highlight
ABSTRACT: Objective
Dipeptidyl peptidase IV (DPP-IV) is not only important in beta-cell function but also has proinflammatory actions. We aimed to investigate whether it could act as a link between low-grade chronic inflammation and diabetes.Research design and methods
Using a case-cohort design, we followed 546 middle-aged individuals who developed diabetes and 538 who did not over approximately 9 years within the Atherosclerosis Risk in Communities study.Results
In weighted analyses, the correlation between DPP-IV levels and anthropometric, inflammatory, or metabolic variables was minimal (Spearman correlations <0.11). Those who developed diabetes had mean DPP-IV values similar to those who did not (P = 0.18). Individuals in the highest quartile of DPP-IV were not at greater risk of diabetes (hazard ratio 0.88 [95% CI 0.62-1.24]) in Cox proportional hazards models adjusting for age, sex, race, study center, and multiple additional diabetes risk factors.Conclusions
Fasting DPP-IV levels do not appear to predict incident diabetes.
SUBMITTER: Luft VC
PROVIDER: S-EPMC2858185 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Luft Vivian C VC Schmidt Maria Inês MI Pankow James S JS Hoogeveen Ron C RC Couper David D Heiss Gerardo G Duncan Bruce B BB
Diabetes care 20100225 5
<h4>Objective</h4>Dipeptidyl peptidase IV (DPP-IV) is not only important in beta-cell function but also has proinflammatory actions. We aimed to investigate whether it could act as a link between low-grade chronic inflammation and diabetes.<h4>Research design and methods</h4>Using a case-cohort design, we followed 546 middle-aged individuals who developed diabetes and 538 who did not over approximately 9 years within the Atherosclerosis Risk in Communities study.<h4>Results</h4>In weighted analy ...[more]