Dataset Information

Markers of oxidative damage are not elevated in otherwise healthy individuals with the metabolic syndrome.

ABSTRACT:

Objective

The role of oxidative damage in the pathogenesis of metabolic syndrome is poorly understood.

Research design and methods

A detailed cross-sectional study was performed to assess the relationship between lipid oxidation products, gamma-glutamyltransferase, high-sensitivity C-reactive protein (hs-CRP), and phospholipase activities with respect to the metabolic status in a cohort of otherwise healthy individuals.

Results

A total of 179 individuals (87 men and 92 women) aged 43 +/- 14 years (mean +/- SD) participated in this study. There were no differences in the levels of plasma F(2)-isoprostanes, hydroxyeicosatetraenoic acids, cholesterol oxidation products, and phospholipase activities in individuals with features of metabolic syndrome. In multivariate analyses, serum hs-CRP was a consistent independent predictor of metabolic syndrome.

Conclusions

Minimal changes were observed in multiple markers of oxidative damage in a well-characterized cohort of individuals with features of metabolic syndrome.

SUBMITTER: Seet RC

PROVIDER: S-EPMC2858191 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature

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Publications

Markers of oxidative damage are not elevated in otherwise healthy individuals with the metabolic syndrome.

Seet Raymond C-S RC Lee Chung-Yung J CY Lim Erle C H EC Quek Amy M L AM Huang Shan-Hong SH Khoo Chin-Meng CM Halliwell Barry B

Diabetes care 20100225 5

<h4>Objective</h4>The role of oxidative damage in the pathogenesis of metabolic syndrome is poorly understood.<h4>Research design and methods</h4>A detailed cross-sectional study was performed to assess the relationship between lipid oxidation products, gamma-glutamyltransferase, high-sensitivity C-reactive protein (hs-CRP), and phospholipase activities with respect to the metabolic status in a cohort of otherwise healthy individuals.<h4>Results</h4>A total of 179 individuals (87 men and 92 wome ...[more]

PMID: 20185735

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Project description:BackgroundMetabolic diseases have been related to gut microbiota, and new knowledge indicates that diet impacts host metabolism through the gut microbiota. Identifying specific gut bacteria associated with both diet and metabolic risk markers may be a potential strategy for future dietary disease prevention. However, studies investigating the association between the gut microbiota, diet, and metabolic markers in healthy individuals are scarce.ObjectiveWe explored the relationship between a panel of gut bacteria, dietary intake, and metabolic and anthropometric markers in healthy adults.DesignForty-nine volunteers were included in this cross-sectional study. Measures of glucose, serum triglyceride, total cholesterol, hemoglobin A1c (HbA1c), blood pressure (BP), and body mass index (BMI) were collected after an overnight fast, in addition to fecal samples for gut microbiota analyzes using a targeted approach with a panel of 48 bacterial DNA probes and assessment of dietary intake by a Food Frequency Questionnaire (FFQ). Correlations between gut bacteria, dietary intake, and metabolic and anthropometric markers were assessed by Pearson's correlation. Gut bacteria varying according to dietary intake and metabolic markers were assessed by a linear regression model and adjusted for age, sex, and BMI.ResultsOf the 48 gut bacteria measured, 24 and 16 bacteria correlated significantly with dietary intake and metabolic and/or anthropometric markers, respectively. Gut bacteria including Alistipes, Lactobacillus spp., and Bacteroides stercoris differed according to the intake of the food components, fiber, sodium, saturated fatty acids, and dietary indices, and metabolic markers (BP and total cholesterol) after adjustments. Notably, Bacteroides stercoris correlated positively with the intake of fiber, grain products, and vegetables, and higher Bacteroides stercoris abundance was associated with higher adherence to Healthy Nordic Food Index (HNFI) and lower diastolic BP after adjustment.ConclusionOur findings highlight the relationship between the gut microbiota, diet, and metabolic markers in healthy individuals. Further investigations are needed to address whether these findings are causally linked and whether targeting these gut bacteria can prevent metabolic diseases.

Dataset Information

Markers of oxidative damage are not elevated in otherwise healthy individuals with the metabolic syndrome.

Objective

Research design and methods

Results

Conclusions

Publications

Markers of oxidative damage are not elevated in otherwise healthy individuals with the metabolic syndrome.

Similar Datasets

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