Domain architecture evolution of pattern-recognition receptors.
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ABSTRACT:
SUBMITTER: Zhang Q
PROVIDER: S-EPMC2858798 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Publications
Domain architecture evolution of pattern-recognition receptors.
Zhang Qing Q Zmasek Christian M CM Godzik Adam A
Immunogenetics 20100302 5
In animals, the innate immune system is the first line of defense against invading microorganisms, and the pattern-recognition receptors (PRRs) are the key components of this system, detecting microbial invasion and initiating innate immune defenses. Two families of PRRs, the intracellular NOD-like receptors (NLRs) and the transmembrane Toll-like receptors (TLRs), are of particular interest because of their roles in a number of diseases. Understanding the evolutionary history of these families a ...[more]
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