Ontology highlight
ABSTRACT:
SUBMITTER: Nava P
PROVIDER: S-EPMC2859189 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Nava Porfirio P Koch Stefan S Laukoetter Mike G MG Lee Winston Y WY Kolegraff Keli K Capaldo Christopher T CT Beeman Neal N Addis Caroline C Gerner-Smidt Kirsten K Neumaier Irmgard I Skerra Arne A Li Linheng L Parkos Charles A CA Nusrat Asma A
Immunity 20100318 3
Inflammatory cytokines have been proposed to regulate epithelial homeostasis during intestinal inflammation. We report here that interferon-gamma (IFN-gamma) regulates the crucial homeostatic functions of cell proliferation and apoptosis through serine-threonine protein kinase AKT-beta-catenin and Wingless-Int (Wnt)-beta-catenin signaling pathways. Short-term exposure of intestinal epithelial cells to IFN-gamma resulted in activation of beta-catenin through AKT, followed by induction of the secr ...[more]