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No association of dysbindin with symptom factors of schizophrenia in an Irish case-control sample.

ABSTRACT: Robust associations between the dysbindin gene (DTNBP1) and schizophrenia have been demonstrated in many but not all samples, and evidence that this gene particularly predisposes to negative symptoms in this illness has been presented. The current study sought to replicate the previously reported negative symptom associations in an Irish case-control sample. Association between dysbindin and schizophrenia has been established in this cohort, and a factor analysis of the assessed symptoms yielded three factors, Positive, Negative, and Schneiderian. The sequential addition method was applied using UNPHASED to assess the relationship between these symptom factors and the high-risk haplotype. No associations were detected for any of the symptom factors indicating that the dysbindin risk haplotype does not predispose to a particular group of symptoms in this sample. Several possibilities, such as differing risk haplotypes, may explain this finding.

SUBMITTER: Bergen SE 

PROVIDER: S-EPMC2859300 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature

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No association of dysbindin with symptom factors of schizophrenia in an Irish case-control sample.

Bergen Sarah E SE   Fanous Ayman H AH   Kuo Po-Hsiu PH   Wormley Brandon K BK   O'Neill F Anthony FA   Walsh Dermot D   Riley Brien P BP   Kendler Kenneth S KS  

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20100301 2

Robust associations between the dysbindin gene (DTNBP1) and schizophrenia have been demonstrated in many but not all samples, and evidence that this gene particularly predisposes to negative symptoms in this illness has been presented. The current study sought to replicate the previously reported negative symptom associations in an Irish case-control sample. Association between dysbindin and schizophrenia has been established in this cohort, and a factor analysis of the assessed symptoms yielded  ...[more]

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