Myosin VI: an innovative motor that challenged the swinging lever arm hypothesis.
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ABSTRACT:
SUBMITTER: Spudich JA
PROVIDER: S-EPMC2859320 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Publications
Myosin VI: an innovative motor that challenged the swinging lever arm hypothesis.
Spudich James A JA Sivaramakrishnan Sivaraj S
Nature reviews. Molecular cell biology 20100201 2
The swinging crossbridge hypothesis states that energy from ATP hydrolysis is transduced to mechanical movement of the myosin head while bound to actin. The light chain-binding region of myosin is thought to act as a lever arm that amplifies movements near the catalytic site. This model has been challenged by findings that myosin VI takes larger steps along actin filaments than early interpretations of its structure seem to allow. We now know that myosin VI does indeed operate by an unusual appr ...[more]
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