Tumor-targeted delivery of biologically active TRAIL protein.
Ontology highlight
ABSTRACT:
SUBMITTER: Zhang HY
PROVIDER: S-EPMC2859322 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Publications
Tumor-targeted delivery of biologically active TRAIL protein.
Zhang H-Y HY Man J-H JH Liang B B Zhou T T Wang C-H CH Li T T Li H-Y HY Li W-H WH Jin B-F BF Zhang P-J PJ Zhao J J Pan X X He K K Gong W-L WL Zhang X-M XM Li A-L AL
Cancer gene therapy 20100115 5
The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a potent inducer of tumor cell apoptosis, but concerns of considerable liver toxicity limit its uses in human cancer therapy. Here, we show that i.v. injected Escherichia coli DH5alpha (E. coli DH5alpha) specifically replicates in solid tumors and metastases in live animals. E. coli DH5alpha does not enter tumor cells and suits for being the vector for soluble TRAIL (sTRAIL), which induces apoptosis by activating cell-s ...[more]
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