Ontology highlight
ABSTRACT:
SUBMITTER: Qin J
PROVIDER: S-EPMC2859433 | biostudies-literature | 2007 Nov
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20070926 47
Acidithiobacillus ferrooxidans has an arsenic resistance operon that is controlled by an As(III)-responsive transcriptional repressor, AfArsR, a member of the ArsR/SmtB family of metalloregulators. AfArsR lacks the As(III) binding site of the ArsRs from plasmid R773 and Escherichia coli, which have a Cys(32)-Val-Cys(34)-Asp-Leu-Cys(37) sequence in the DNA binding site. In contrast, it has three cysteine residues, Cys(95), Cys(96), and Cys(102), that are not present in the R773 and E. coli ArsRs. ...[more]