Ontology highlight
ABSTRACT:
SUBMITTER: Visschedyk DD
PROVIDER: S-EPMC2859513 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20100224 18
Photorhabdus luminescens is a pathogenic bacterium that produces many toxic proteins. The mono-ADP-ribosyltransferases (mARTs) are an enzyme class produced by numerous pathogenic bacteria and participate in disease in plants and animals, including humans. Herein we report a novel mART from P. luminescens called Photox. This 46-kDa toxin shows high homology to other actin-targeting mARTs in hallmark catalytic regions and a similar core catalytic fold. Furthermore, Photox shows in vivo cytotoxic a ...[more]