Ontology highlight
ABSTRACT:
SUBMITTER: Carrera S
PROVIDER: S-EPMC2859528 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Carrera Samantha S de Verdier Petra J PJ Khan Zahid Z Zhao Bo B Mahale Alka A Bowman Karen J KJ Zainol Muri M Jones George D D GD Lee Sam W SW Aaronson Stuart A SA Macip Salvador S
The Journal of biological chemistry 20100312 18
Oxygen availability has important effects on cell physiology. Although hyperoxic and hypoxic stresses have been well characterized, little is known about cellular functions in the oxygen levels commonly found in vivo. Here, we show that p53-dependent apoptosis in response to different DNA-damaging agents was reduced when normal and cancer cells were cultured at physiological oxygen tensions instead of the usual atmospheric levels. Different from what has been described in hypoxia, this was neith ...[more]