Ontology highlight
ABSTRACT:
SUBMITTER: Francisco AB
PROVIDER: S-EPMC2859532 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Francisco Adam B AB Singh Rajni R Li Shuai S Vani Anish K AK Yang Liu L Munroe Robert J RJ Diaferia Giuseppe G Cardano Marina M Biunno Ida I Qi Ling L Schimenti John C JC Long Qiaoming Q
The Journal of biological chemistry 20100302 18
Stress in the endoplasmic reticulum (ER) plays an important causal role in the pathogenesis of several chronic diseases such as Alzheimer, Parkinson, and diabetes mellitus. Insight into the genetic determinants responsible for ER homeostasis will greatly facilitate the development of therapeutic strategies for the treatment of these debilitating diseases. Suppressor enhancer Lin12 1 like (SEL1L) is an ER membrane protein and was thought to be involved in the quality control of secreted proteins. ...[more]