CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid.
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ABSTRACT:
SUBMITTER: Giedraitis V
PROVIDER: S-EPMC2860374 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Publications
CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid.
Giedraitis Vilmantas V Glaser Anna A Sarajärvi Timo T Brundin RoseMarie R Gunnarsson Malin Degerman MD Schjeide Brit-Maren BM Tanzi Rudolph E RE Helisalmi Seppo S Pirttilä Tuula T Kilander Lena L Lannfelt Lars L Soininen Hilkka H Bertram Lars L Ingelsson Martin M Hiltunen Mikko M
Neuroscience letters 20091223 2
Recently, the P86L alteration in CALHM1 (calcium homeostasis modulator-1) was reported to be associated with Alzheimer's disease (AD). Moreover, the risk allele increased amyloid-beta (A beta) levels in conditioned media from cultured cells. Therefore, we hypothesized that CALHM1 P86L may modulate A beta or tau levels in cerebrospinal fluid (CSF). Nearly 200 individuals with AD or other cognitive disorders were included for CSF analysis and CALHM1 genotyping. No significant differences in CSF le ...[more]
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