Ontology highlight
ABSTRACT:
SUBMITTER: Dohm MT
PROVIDER: S-EPMC2860423 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Dohm Michelle T MT Seurynck-Servoss Shannon L SL Seo Jiwon J Zuckermann Ronald N RN Barron Annelise E AE
Biopolymers 20090101 6
A family of peptoid dimers developed to mimic SP-B is presented, where two amphipathic, cationic helices are linked by an achiral octameric chain. SP-B is a vital therapeutic protein in lung surfactant replacement therapy, but its large-scale isolation or chemical synthesis is impractical. Enhanced biomimicry of SP-B's disulfide-bonded structure has been previously attempted via disulfide-mediated dimerization of SP-B(1-25) and other peptide mimics, which improved surface activity relative to th ...[more]