Ontology highlight
ABSTRACT:
SUBMITTER: Marchand C
PROVIDER: S-EPMC2860603 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Marchand Christophe C Maddali Kasthuraiah K Métifiot Mathieu M Pommier Yves Y
Current topics in medicinal chemistry 20090101 11
Integrase (IN) is the newest validated target against AIDS and retroviral infections. The remarkable activity of raltegravir (Isentress((R))) led to its rapid approval by the FDA in 2007 as the first IN inhibitor. Several other IN strand transfer inhibitors (STIs) are in development with the primary goal to overcome resistance due to the rapid occurrence of IN mutations in raltegravir-treated patients. Thus, many scientists and drug companies are actively pursuing clinically useful IN inhibitors ...[more]