Ontology highlight
ABSTRACT:
SUBMITTER: Chan YA
PROVIDER: S-EPMC2860681 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Biochemistry 20100501 17
Polyketide synthases elongate a polyketide backbone by condensing carboxylic acid precursors that are thioesterified to either coenzyme A or an acyl carrier protein (ACP). Two of the three known ACP-linked extender units, (2S)-aminomalonyl-ACP and (2R)-hydroxymalonyl-ACP, are found in the biosynthesis of the agriculturally important antibiotic zwittermicin A. We previously reconstituted the formation of (2S)-aminomalonyl-ACP and (2R)-hydroxymalonyl-ACP from the primary metabolites l-serine and 1 ...[more]