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Cytotoxic polyisoprenyl benzophenonoids from Garcinia subelliptica.

ABSTRACT: Six new polyisoprenyl benzophenonoids, (+/-)-garcinialiptone A (1, 2), garcinialiptone B (3), (-)-cycloxanthochymol (4), garcinialiptone C (5), and garcinialiptone D (6), along with three known compounds, xanthochymol (7), isoxanthochymol (8), and cycloxanthochymol (9), were isolated from the fruits of Garcinia subelliptica. The structures of 1-6 were elucidated by spectroscopic analysis. Biological evaluation showed that all compounds 1-9 exhibited cytotoxic activity against a small panel of human tumor cell lines (A549, DU145, KB, vincristine-resistant KB).

SUBMITTER: Zhang LJ

PROVIDER: S-EPMC2860718 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature

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Cytotoxic polyisoprenyl benzophenonoids from Garcinia subelliptica.

Zhang Li-Jie LJ Chiou Chun-Tang CT Cheng Jing-Jy JJ Huang Hui-Chi HC Kuo Li-Ming Yang LM Liao Chia-Chin CC Bastow Kenneth F KF Lee Kuo-Hsiung KH Kuo Yao-Haur YH

Journal of natural products 20100401 4

Six new polyisoprenyl benzophenonoids, (+/-)-garcinialiptone A (1, 2), garcinialiptone B (3), (-)-cycloxanthochymol (4), garcinialiptone C (5), and garcinialiptone D (6), along with three known compounds, xanthochymol (7), isoxanthochymol (8), and cycloxanthochymol (9), were isolated from the fruits of Garcinia subelliptica. The structures of 1-6 were elucidated by spectroscopic analysis. Biological evaluation showed that all compounds 1-9 exhibited cytotoxic activity against a small panel of hu ...[more]

PMID: 20232858

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