Ontology highlight
ABSTRACT:
SUBMITTER: Dykstra KM
PROVIDER: S-EPMC2861614 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Dykstra Kaitlyn M KM Pokusa Jacqueline E JE Suhan Joseph J Lee Tina H TH
Molecular biology of the cell 20100317 9
The structure of the endoplasmic reticulum (ER) undergoes highly regulated changes in specialized cell types. One frequently observed type of change is its reorganization into stacked and concentrically whorled membranes, but the underlying mechanisms and functional relevance for cargo export are unknown. Here, we identify Yip1A, a conserved membrane protein that cycles between the ER and early Golgi, as a key mediator of ER organization. Yip1A depletion led to restructuring of the network into ...[more]