Complement as an endogenous adjuvant for dendritic cell-mediated induction of retrovirus-specific CTLs.
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ABSTRACT:
SUBMITTER: Banki Z
PROVIDER: S-EPMC2861708 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
Complement as an endogenous adjuvant for dendritic cell-mediated induction of retrovirus-specific CTLs.
Bánki Zoltán Z Posch Wilfried W Ejaz Asim A Oberhauser Verena V Willey Suzanne S Gassner Christoph C Stoiber Heribert H Dittmer Ulf U Dierich Manfred P MP Hasenkrug Kim J KJ Wilflingseder Doris D
PLoS pathogens 20100429 4
Previous studies have demonstrated the involvement of complement (C) in induction of efficient CTL responses against different viral infections, but the exact role of complement in this process has not been determined. We now show that C opsonization of retroviral particles enhances the ability of dendritic cells (DCs) to induce CTL responses both in vitro and in vivo. DCs exposed to C-opsonized HIV in vitro were able to stimulate CTLs to elicit antiviral activity significantly better than non-o ...[more]
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